Zolmitriptan

Zolmitriptan

• CAS Number: 139264-17-8
• UNSPSC Description: Zolmitriptan (BW-311C90; 311C90) is a 5-HT1B/1D receptor partial agonist with Kis of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, 5-HT1F receptor, respectively. Zolmitriptan can be used for the research of migraine[1][2].
• Target Antigen: 5-HT Receptor; Endogenous Metabolite
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Zolmitriptan.html
• Purity: 99.98
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C1OC[C@H](CC2=CC3=C(NC=C3CCN(C)C)C=C2)N1
• Molecular Weight: 287.36
• References & Citations: [1]G R Martin, et al. Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan). Br J Pharmacol. 1997 May;121(2):157-64.|[2]Katherine C Murray, et al. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 2011 Aug;106(2):925-43.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched