Zolmitriptan

• Description :

  Zolmitriptan (BW-311C90; 311C90) is a 5-HT1B/1D receptor partial agonist with Kis of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, 5-HT1F receptor, respectively. Zolmitriptan can be used for the research of migraine[1][2].

• Product Name Alternative :

  BW-311C90; 311C90

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H371

• Target :

  5-HT Receptor; Endogenous Metabolite

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Zolmitriptan.html

• Purity :

  99.98

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1OC[C@H](CC2=CC3=C(NC=C3CCN(C)C)C=C2)N1

• Molecular Formula :

  C16H21N3O2

• Molecular Weight :

  287.36

• Precautions :

  H302, H371

• References & Citations :

  [1]G R Martin, et al. Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan) . Br J Pharmacol. 1997 May;121 (2) :157-64.|[2]Katherine C Murray, et al. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 2011 Aug;106 (2) :925-43.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT1 Receptor; mLAG-3

• CAS Number :

  [139264-17-8]