1alpha-Hydroxy VD4

• Description :

  1alpha-Hydroxy VD4, a 1alpha (OH) D derivative, can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU and P31/FUJ cells.

• CAS Number :

  [143032-85-3]

• Product Name Alternative :

  1α-Hydroxy vitamin D4

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  VD/VDR

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/1alpha-hydroxy-vd4.html

• Purity :

  98.41

• Solubility :

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  C=C1[C@@H](O)C[C@H](O)C/C1=C/C=C2[C@@](CC[C@@H]3[C@H](C)CC[C@H](C)C(C)C)([H])[C@]3(C)CCC/2

• Molecular Formula :

  C28H46O2

• Molecular Weight :

  414.66

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]M Makishima, et al. Growth inhibition and differentiation induction in human monoblastic leukaemia cells by 1alpha-hydroxyvitamin D derivatives and their enhancement by combination with hydroxyurea. British Journal of Cancer (1998) 77, 33-39

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported