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MTX115325

CAT: 0804-HY-160019-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160019-01Size:1 mg
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Description
MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine[1].
CAS Number
2750895-97-5
UNSPSC
12352005
Target
Deubiquitinase; Mitophagy
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mtx115325.html
Purity
99.91
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=C(C2=CC=NC(C#N)=C2)O1)N3[C@]4([H])[C@@](CC3)([H])[C@H](N(C4)C#N)C
Molecular Formula
C18H16N6O2
Molecular Weight
348.36
References & Citations
[1]Fang TZ et al. Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model. Nat Commun. 2023 Nov 13;14 (1) :7295.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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GTR19234945-01MTX115325

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