Products for Research Use Only
RegisterLogin

MTX115325

CAT: 0931-T86936-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T86936-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2750895-97-5
Target
DUB, Mitophagy
Related Pathways
DNA Damage/DNA Repair, Ubiquitination, Autophagy, Cell Cycle/Checkpoint
Bioactivity
MTX115325 (Example 1) is a brain-penetrant USP30 inhibitor with an IC 50 of 12 nM, administered orally and exhibiting neuroprotective properties. It enhances ubiquitination (EC 50 =32 nM) of TOM20, a mitochondrial outer membrane protein and USP30 substrate, thereby promoting mitophagy. Additionally, MTX115325 prevents dopaminergic neuron loss and maintains striatal dopamine [1].
Smiles
C(=O)(N1[C@@]2([C@@]([C@@H](C)N(C#N)C2)(CC1)[H])[H])C=3OC(=CN3)C=4C=C(C#N)N=CC4
Molecular Formula
C18H16N6O2
Molecular Weight
348.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-160019-01MTX115325

Popular Products