BAY-678

CAT: 0026-B3061-25Size: 25 mgDry Ice: NoHazardous: No
CAT#:0026-B3061-25Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY-678 is a potent, selective, cell-permeable inhibitor of human neutrophil elastase (HNE).The activity of HNE is increased in inflammatory diseases. BAY-678 shows Ki values of 15 nM and 600 nM for human and rat neutrophil elastase respectively and IC₅₀ of 20 nM in vitro. It shows beneficial pulmonary hemodynamic and vascular effects in animal models of pulmonary arterial hypertension. The S-enantiomer BAY-677 is a negative control for BAY-678.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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