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BAY-678

CAT: 0804-HY-111457A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111457A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC) .
CAS Number
675103-36-3
UNSPSC
12352005
Target
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/BAY-678.html
Concentration
10mM
Purity
99.59
Solubility
DMSO : ≥ 100 mg/mL|Ethanol : ≥ 4.76 mg/mL
Smiles
N#CC1=NC=C([C@H](C(C(C)=O)=C(C)N2C3=CC=CC(C(F)(F)F)=C3)NC2=O)C=C1
Molecular Formula
C20H15F3N4O2
Molecular Weight
400.35
References & Citations
[1]von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10 (7) :1163-73.|[2]von Nussbaum F, et al. Neutrophil elastase inhibitors for the treatment of (cardio) pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores. Bioorg Med Chem Lett. 2015 Oct 15;25 (20) :4370-81.|[3]BAY-678 Selective chemical probe for Human Neutrophil Elastase.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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