BAY-678

• Description :

  BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC) .

• UNSPSC :

  12352005

• Target :

  Elastase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/BAY-678.html

• Concentration :

  10mM

• Purity :

  99.59

• Solubility :

  DMSO : ≥ 100 mg/mL|Ethanol : ≥ 4.76 mg/mL

• Smiles :

  N#CC1=NC=C([C@H](C(C(C)=O)=C(C)N2C3=CC=CC(C(F)(F)F)=C3)NC2=O)C=C1

• Molecular Formula :

  C20H15F3N4O2

• Molecular Weight :

  400.35

• References & Citations :

  [1]von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10 (7) :1163-73.|[2]von Nussbaum F, et al. Neutrophil elastase inhibitors for the treatment of (cardio) pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores. Bioorg Med Chem Lett. 2015 Oct 15;25 (20) :4370-81.|[3]BAY-678 Selective chemical probe for Human Neutrophil Elastase.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [675103-36-3]