RIPA-56

CAT: 0026-B3051-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-B3051-5Size:5 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with an IC₅₀ of 13 nM. It protects HT-29 cells against TNFα-induced necroptosis with an EC₅₀ of 28 nM. RIPA-56 efficiently reduces TNFα-induced mortality and multiorgan damage in a systemic inflammatory response syndrome (SIRS) mice model. Modulators of RIP kinase 1 may be beneficial against SARS-CoV-2 based on interaction of RIP kinase 1 with SARS-CoV-2 protein Nsp12.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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