YW3-56 (hydrochloride)

CAT: 0026-B2858-1000Size: 1000 µgDry Ice: NoHazardous: No

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CAT#:0026-B2858-1000Size:1000 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

YW3-56 is an inhibitor of protein arginine deiminases PAD2 and PAD4 which convert protein arginine residues to citrulline. The IC₅₀ for inhibition of PAD4 and PAD2 is about 1–2 μM and 0.5–1 μM respectively. YW3-56 inhibits the growth of osteosarcoma U2OS cells with an IC₅₀ of 2.5 μM. YW3-56 induces p53 target genes SESN2 and DDIT4 which repress mTORC1 kinase activity. It perturbs autophagy and inhibits the growth of triple-negative breast cancer xenograft tumors in mice.

Shipping Conditions

Gel Pack

Storage Conditions

-20ºC

Shelf Life

24months

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YW3-56 (hydrochloride)

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