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AMTB hydrochloride

CAT: 0026-B2978-25Size: 25 mgDry Ice: NoHazardous: No
CAT#:0026-B2978-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMTB is an antagonist of transient receptor potential melastatin 8 (TRPM8). It inhibits icilin-induced calcium influx with a pIC₅₀ of 6.23. Intravenous administration of AMTB (3 mg/kg) decreases the frequency of volume-induced urinary bladder contractions, without reducing the amplitude of contraction in a rat model. It inhibits the response to noxious bladder stimulation at 10 mg/kg. AMTB also inhibits the sodium channel (Nav) isoforms Nav1.1-1.9 with IC₅₀ values of 2 µM-14.8 µM and decreases viability of MDA-MB-231 and SK-BR-3 breast cancer cells with IC₅₀ values of ~23.7 µM and 17.3 µM, respectively in a TRPM8-independent manner.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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