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BSB

CAT: 0804-HY-D1443-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D1443-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BSB is a Congo red-derived fluorescent probe. BSB binds not only to extracellular amyloid β protein, but also many intracellular lesions composed of abnormal tau and synuclein proteins. BSB acts as a prototype imaging agent for Alzheimer's disease[1].
CAS Number
291766-06-8
Product Name Alternative
(trans, trans) -1-Bromo-2,5-bis- (3-hydroxycarbonyl-4-hydroxy) styrylbenzene
UNSPSC
12171500
Target
Amyloid-β
Type
Dye Reagents
Related Pathways
Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/bsb.html
Purity
97.24
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
BrC1=CC(/C=C/C2=CC=C(O)C(C(O)=O)=C2)=CC=C1/C=C/C3=CC=C(O)C(C(O)=O)=C3
Molecular Formula
C24H17BrO6
Molecular Weight
481.29
References & Citations
[1]M L Schmidt, et al. The fluorescent Congo red derivative, (trans, trans) -1-bromo-2,5-bis- (3-hydroxycarbonyl-4-hydroxy) styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains. Am J Pathol. 2001 Sep;159 (3) :937-43.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

Chemical Information

1-Bromo-2,5-bis(3-carboxy-4-hydroxystyryl)benzene
CAS Number291766-06-8
PubChem CID10184360
IUPAC Name5-[(E)-2-[3-bromo-4-[(E)-2-(3-carboxy-4-hydroxyphenyl)ethenyl]phenyl]ethenyl]-2-hydroxybenzoic acid
Molecular FormulaC24H17BrO6
Molecular Weight481.3
XLogP6.6
Topological Polar Surface Area115
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count31
Formal Charge0
Complexity692
SMILES
C1=CC(=C(C=C1/C=C/C2=CC(=C(C=C2)O)C(=O)O)Br)/C=C/C3=CC(=C(C=C3)O)C(=O)O
InChI
InChI=1S/C24H17BrO6/c25-20-13-16(2-1-14-5-9-21(26)18(11-14)23(28)29)4-8-17(20)7-3-15-6-10-22(27)19(12-15)24(30)31/h1-13,26-27H,(H,28,29)(H,30,31)/b2-1+,7-3+
InChIKey
ZVECSLHUCRIBDY-WMWQKROPSA-N
Chemical Structure
2D Structure
2D structure of 1-Bromo-2,5-bis(3-carboxy-4-hydroxystyryl)benzene
CAS: 291766-06-8
CID: 10184360
Formula: C24H17BrO6
MW: 481.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight481.3
XLogP36.6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass480.02085
Monoisotopic Mass480.02085
Topological Polar Surface Area115 Ų
Heavy Atom Count31
Formal Charge0
Complexity692
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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