BSB

• Description:

  BSB is a Congo red-derived fluorescent probe. BSB binds not only to extracellular amyloid β protein, but also many intracellular lesions composed of abnormal tau and synuclein proteins. BSB acts as a prototype imaging agent for Alzheimer's disease[1].

• Product Name Alternative:

  (trans, trans) -1-Bromo-2,5-bis- (3-hydroxycarbonyl-4-hydroxy) styrylbenzene

• UNSPSC:

  12171500

• Target:

  Amyloid-β

• Type:

  Dye Reagents

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/bsb.html

• Purity:

  97.24

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  BrC1=CC(/C=C/C2=CC=C(O)C(C(O)=O)=C2)=CC=C1/C=C/C3=CC=C(O)C(C(O)=O)=C3

• Molecular Formula:

  C24H17BrO6

• Molecular Weight:

  481.29

• References & Citations:

  [1]M L Schmidt, et al. The fluorescent Congo red derivative, (trans, trans) -1-bromo-2,5-bis- (3-hydroxycarbonyl-4-hydroxy) styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains. Am J Pathol. 2001 Sep;159 (3) :937-43.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [291766-06-8]