Naphazoline (hydrochloride)
CAT:
804-HY-B0446-02
Size:
1 g
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Naphazoline (hydrochloride)
- CAS Number: 550-99-2
- UNSPSC Description: Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research[1][2].
- Target Antigen: Adrenergic Receptor; Interleukin Related; TNF Receptor; VEGFR
- Type: Reference compound
- Related Pathways: Apoptosis;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling;Protein Tyrosine Kinase/RTK
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology; Cardiovascular Disease; Cancer
- Assay Protocol: https://www.medchemexpress.com/naphazoline-hydrochloride.html
- Purity: 98.12
- Solubility: DMSO : ≥ 25 mg/mL|H2O : 50 mg/mL (ultrasonic)
- Smiles: C1(CC2=NCCN2)=CC=CC3=CC=CC=C13.Cl
- Molecular Weight: 246.74
- References & Citations: [1]Quan L, et, al. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. Mol Med Rep. 2016 Apr;13(4):3319-25.|[2]Yamaguchi I, et, al. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203(1):125-31.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched