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Cyclo (his-pro)

CAT: 0804-HY-101402-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101402-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclo (his-pro) (Cyclo (histidyl-proline) ) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone[1]. Cyclo (his-pro) could inhibit NF-κB nuclear accumulation. Cyclo (his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses[2].
CAS Number
53109-32-3
Product Name Alternative
Cyclo (histidyl-proline) ; Histidylproline diketopiperazine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; NF-κB
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Cyclo_his-pro_.html
Purity
99.41
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 30 mg/mL
Smiles
O=C(N[C@H]1CC2=CN=CN2)[C@@](CCC3)([H])N3C1=O
Molecular Formula
C11H14N4O2
Molecular Weight
234.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Grottelli S, et al. The Role of Cyclo (His-Pro) in Neurodegeneration. Int J Mol Sci. 2016 Aug 12;17 (8) . pii: E1332.|[2]Minelli A, et al. Cyclo (His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling. Int J Biochem Cell Biol. 2012 Mar;44 (3) :525-35.|[3]Bellezza I, et al. Neuroinflammation and endoplasmic reticulum stress are coregulated by cyclo (His-Pro) to prevent LPS neurotoxicity. Int J Biochem Cell Biol. 2014 Jun;51:159-69.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; NF-κB

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