Cyclo (Phe-Pro)

• Description :

  Cyclo (Phe-Pro) (Cyclo (phenylalanylprolyl) ) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo (Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo (Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance[1][2][3].

• Product Name Alternative :

  Cyclo (phenylalanylprolyl) ; A-64863

• UNSPSC :

  12352209

• Hazard Statement :

  H302, H315, H319

• Target :

  Antibiotic; Bacterial; HCV; Reactive Oxygen Species (ROS)

• Type :

  Peptides

• Related Pathways :

  Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/cyclo-phe-pro.html

• Purity :

  98.77

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1NC(C(N2C1CCC2)=O)CC3=CC=CC=C3

• Molecular Formula :

  C14H16N2O2

• Molecular Weight :

  244.29

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Lee W, et al. Vibrio vulnificus quorum-sensing molecule cyclo (Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9 (1) :1606.|[2]Bina XR, et al. The cyclic dipeptide cyclo (Phe-Pro) inhibits cholera toxin and toxin-coregulated pilus production in O1 El Tor Vibrio cholerae. J Bacteriol. 2010 Jul;192 (14) :3829-32.|[3]Wang Y, et al. Novel application of cyclo (-Phe-Pro) in mitigating aluminum toxicity through oxidative stress alleviation in wheat roots. Environ Pollut. 2024 Dec 15;363 (Pt 2) :125241.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [14705-60-3]