Cyclo (Phe-Pro)

CAT: 0804-HY-P1934-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P1934-01Size:5 mg
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Description
Cyclo (Phe-Pro) (Cyclo (phenylalanylprolyl) ) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo (Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo (Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance[1][2][3].
CAS Number
[14705-60-3]
Product Name Alternative
Cyclo (phenylalanylprolyl) ; A-64863
UNSPSC
12352209
Hazard Statement
H302, H315, H319
Target
Antibiotic; Bacterial; HCV; Reactive Oxygen Species (ROS)
Type
Peptides
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cyclo-phe-pro.html
Purity
98.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC(C(N2C1CCC2)=O)CC3=CC=CC=C3
Molecular Formula
C14H16N2O2
Molecular Weight
244.29
Precautions
H302, H315, H319
References & Citations
[1]Lee W, et al. Vibrio vulnificus quorum-sensing molecule cyclo (Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9 (1) :1606.|[2]Bina XR, et al. The cyclic dipeptide cyclo (Phe-Pro) inhibits cholera toxin and toxin-coregulated pilus production in O1 El Tor Vibrio cholerae. J Bacteriol. 2010 Jul;192 (14) :3829-32.|[3]Wang Y, et al. Novel application of cyclo (-Phe-Pro) in mitigating aluminum toxicity through oxidative stress alleviation in wheat roots. Environ Pollut. 2024 Dec 15;363 (Pt 2) :125241.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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