Tea polyphenol

CAT: 0804-HY-N1925-02Size: 5 gDry Ice: NoHazardous: No

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CAT#:0804-HY-N1925-02Size:5 g

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Description

Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism[1].

CAS Number

84650-60-2

UNSPSC

12352005

Hazard Statement

H225, H226, H319

Target

Apoptosis; Autophagy

Type

Natural Products

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tea-polyphenol.html

Purity

99.0

Solubility

DMSO : 32.5 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

[Teapolyphenol]

Precautions

H225, H226, H319

References & Citations

[1]Suzuki J, et al. Tea polyphenols regulate key mediators on inflammatory cardiovascular diseases. Mediators Inflamm. 2009;2009:494928.|[2]Chen D, et al. Tea polyphenols, their biological effects and potential molecular targets. Histol Histopathol. 2008 Apr;23 (4) :487-96.|[3]Mao X, et al. Oxidative stress-induced diseases and tea polyphenols. Oncotarget. 2017 Sep 14;8 (46) :81649-81661.|[4]Hui Zhou, et al. Regulation of autophagy by tea polyphenols in diabetic cardiomyopathy. J Zhejiang Univ Sci B. 2018 May;19 (5) :333-341.|[5]Xu Y, et al. Green tea polyphenols inhibit cognitive impairment induced by chronic cerebral hypoperfusion via modulating oxidative stress. J Nutr Biochem. 2010 Aug;21 (8) :741-8.|[6]Zhu WL, et al. Green tea polyphenols produce antidepressant-like effects in adult mice. Pharmacol Res. 2012 Jan;65 (1) :74-80. |[7]Chen X, et al. Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression. World J Gastroenterol. 2009 Apr 21;15 (15) :1829-35.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Chemical Information

Tea, ext.

5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate is a catechin.

CAS Number	84650-60-2
PubChem CID	1287
IUPAC Name	[5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
Molecular Formula	C22H18O11
Molecular Weight	458.4
XLogP	1.2
Topological Polar Surface Area	197
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	4
Heavy Atom Count	33
Formal Charge	0
Complexity	667

SMILES

C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

InChI

InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2

InChIKey

WMBWREPUVVBILR-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 84650-60-2

CID: 1287

Formula: C22H18O11

MW: 458.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	458.4
XLogP3	1.2
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	4
Exact Mass	458.08491139
Monoisotopic Mass	458.08491139
Topological Polar Surface Area	197 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	667
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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