Methyltetrazine-DBCO (TEA)

• Description:

  Methyltetrazine-DBCO TEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-DBCO TEA is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-DBCO TEA also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups[1].

• UNSPSC:

  12352005

• Target:

  ADC Linker

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  CCN(CC)CC.O=S(C(CNC(CCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O)=O)C(NCCCOC4=CC=C(C5=NN=C(C)N=N5)C=C4)=O)(O)=O

• Molecular Formula:

  C40H48N8O7S

• Molecular Weight:

  784.92

• References & Citations:

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported