Methyltetrazine-DBCO (TEA)

CAT: 0804-HY-140313ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-140313ASize:1 Each
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methyltetrazine-DBCO TEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-DBCO TEA is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-DBCO TEA also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups[1].
UNSPSC
12352005
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CCN(CC)CC.O=S(C(CNC(CCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O)=O)C(NCCCOC4=CC=C(C5=NN=C(C)N=N5)C=C4)=O)(O)=O
Molecular Formula
C40H48N8O7S
Molecular Weight
784.92
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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