AJI-214

• Description:

  AJI-214 is a dual-target inhibitor of Aurora kinase A and JAK2. AJI-214 directly blocks Aurora kinase A to inhibit T cell mitotic progression and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-214 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD) [1].

• UNSPSC:

  12352005

• Target:

  Aurora Kinase; JAK; Mitosis; STAT

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/aji-214.html

• Smiles:

  O=C (C1=CC=C (NC2=NC=C (C (NC3=C (Cl) C=CC=C3) =N2) F) C=C1) N

• Molecular Formula:

  C17H13ClFN5O

• Molecular Weight:

  357.77

• References & Citations:

  [1]Betts, et al. "Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function." Science translational medicine 9.372 (2017) : eaai8269.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1395886-20-0