AJI-214

CAT: 0804-HY-164455Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-164455Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AJI-214 is a dual-target inhibitor of Aurora kinase A and JAK2. AJI-214 directly blocks Aurora kinase A to inhibit T cell mitotic progression and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-214 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD) [1].
CAS Number
[1395886-20-0]
UNSPSC
12352005
Target
Aurora Kinase; JAK; Mitosis; STAT
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/aji-214.html
Smiles
O=C(C1=CC=C(NC2=NC=C(C(NC3=C(Cl)C=CC=C3)=N2)F)C=C1)N
Molecular Formula
C17H13ClFN5O
Molecular Weight
357.77
References & Citations
[1]Betts, et al. "Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function." Science translational medicine 9.372 (2017) : eaai8269.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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