ML-00253764 (hydrochloride)

ML-00253764 (hydrochloride)

• CAS Number: 1706524-94-8
• UNSPSC Description: ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 μM and 0.103 μM, respectively[1].
• Target Antigen: Melanocortin Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Cancer; Endocrinology
• Assay Protocol: https://www.medchemexpress.com/ml-00253764-hydrochloride.html
• Purity: 99.47
• Solubility: DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: FC1=C(CCC2=CC(Br)=CC=C2OC)C(C3=NCCN3)=CC=C1.[H]Cl
• Molecular Weight: 413.71
• References & Citations: [1]Vos TJ, et al. Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. J Med Chem. 2004 Mar 25;47(7):1602-4.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported