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Cathepsin L-IN-2

CAT: 0804-HY-115733-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115733-01Size:1 mg
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Description
Cathepsin L-IN-2 ((Rac) -Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK , with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.
CAS Number
108005-94-3
Product Name Alternative
(Rac) -Z-Phe-Phe-FMK
UNSPSC
12352005
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cathepsin-l-in-2.html
Purity
98.02
Solubility
DMSO : 42.5 mg/mL (ultrasonic)
Smiles
O=C(OCC1=CC=CC=C1)NC(CC2=CC=CC=C2)C(NC(CC3=CC=CC=C3)C(CF)=O)=O
Molecular Formula
C27H27FN2O4
Molecular Weight
462.51
References & Citations
[1]Jonathan Frew, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020 Mar 16;15 (1) :21.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin L

Chemical Information

Cathepsin L Inhibitor I
CAS Number108005-94-3
PubChem CID16760359
IUPAC Namebenzyl N-[1-[(4-fluoro-3-oxo-1-phenylbutan-2-yl)amino]-1-oxo-3-phenylpropan-2-yl]carbamate
Molecular FormulaC27H27FN2O4
Molecular Weight462.5
XLogP4.9
Topological Polar Surface Area84.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count12
Heavy Atom Count34
Formal Charge0
Complexity641
SMILES
C1=CC=C(C=C1)CC(C(=O)CF)NC(=O)C(CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3
InChI
InChI=1S/C27H27FN2O4/c28-18-25(31)23(16-20-10-4-1-5-11-20)29-26(32)24(17-21-12-6-2-7-13-21)30-27(33)34-19-22-14-8-3-9-15-22/h1-15,23-24H,16-19H2,(H,29,32)(H,30,33)
InChIKey
CAILNONEKASNSH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cathepsin L Inhibitor I
CAS: 108005-94-3
CID: 16760359
Formula: C27H27FN2O4
MW: 462.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight462.5
XLogP34.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count12
Exact Mass462.19548551
Monoisotopic Mass462.19548551
Topological Polar Surface Area84.5 Ų
Heavy Atom Count34
Formal Charge0
Complexity641
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS5802675Cathepsin L-IN-2
216174Cathepsin L (CATL, Cathepsin-L)
GTR19263127-01Mpro/Cathepsin L-IN-2
sc-32320Cathepsin L (33/2)
545790Cathepsin L
sc-32320 ACCathepsin L (33/2) AC
sc-32320 HRPCathepsin L (33/2) HRP
sc-32320 PECathepsin L (33/2) PE
sc-32320 FITCCathepsin L (33/2) FITC
478793CTSL1 (Cathepsin L1, Cathepsin L)

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