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BW-180C

CAT: 0804-HY-105343-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-105343-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BW-180C ([D-Ala2, D-Leu5]-Enkephalin; DADLE) is an δ opioid receptor (DOR) agonist, which belongs to the enkephalin family. Neuroprotective agent. BW-180C reversibly inhibits cellular transcription in neurons without causing cell injury[1].
CAS Number
63631-40-3
Product Name Alternative
[D-Ala2, D-Leu5]-Enkephalin; DADLE
UNSPSC
12352209
Target
Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/DADLE.html
Purity
99.92
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CC(C)C[C@H](C(O)=O)NC([C@@H](NC(CNC([C@@H](C)NC([C@@H](N)CC1=CC=C(O)C=C1)=O)=O)=O)CC2=CC=CC=C2)=O
Molecular Formula
C29H39N5O7
Molecular Weight
569.65
References & Citations
[1]Jie Tian, et al. [D-Ala2, D-Leu5] encephalin (DADLE) reversibly inhibits cellular transcription in neurons without causing cell injury. Brain Res. 2014 May 27;1565:1-7.|[2]Kousyou Yamanouchi, et al. [D-Ala2, D-Leu5] enkephalin (DADLE) protects liver against ischemia-reperfusion injury in the rat. J Surg Res. 2003 Sep;114 (1) :72-7.|[3]Zhou Y, et al. DADLE improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO‑1 pathway. Mol Med Rep. 2017 Nov;16 (5) :6214-6221.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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