ONC213

CAT: 0804-HY-164515-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-164515-01Size:5 mg
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Description
ONC213 is an orally active αKGDH inhibitor. ONC213 can suppress mitochondrial respiration and elevate α-ketoglutarate levels by inhibiting αKGDH activity. ONC213 can induce cells apoptosis by inducing mitochondrial stress response and inhibiting translation of MCL-1. ONC213 can be used for the research of cancer, such as acute myeloid leukemia research (AML) [1].
CAS Number
[1977540-13-8]
UNSPSC
12352005
Target
Apoptosis; Caspase; Mitochondrial Metabolism; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/onc213.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(CC2=CC=C(F)C(F)=C2)C3=NCCN3C4=C1CN(CC4)CC5=CC=CC=C5
Molecular Formula
C23H22F2N4O
Molecular Weight
408.44
References & Citations
[1]Su Y, et al. The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia. Cancer Res. 2024 Apr 1;84 (7) :1084-1100.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3

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