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ONC1-13B

CAT: 0804-HY-114246-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114246-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ONC1-13B is a potent androgen receptor (AR) antagonist with the activity of effectively inhibiting PSA expression in prostate cancer cells. ONC1-13B can effectively inhibit PSA expression and prostate cancer cell proliferation under DHT stimulation. ONC1-13B exerts its anti-tumor effect by preventing androgen from binding to AR and its nuclear translocation[1].
CAS Number
1351185-54-0
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/onc1-13b.html
Smiles
O=C1[C@]2(CCOC2)N(C3=CC(F)=C(C=C3)C(NC)=O)C(N1C4=CC(C(F)(F)F)=C(C=C4)C#N)=S
Molecular Formula
C22H16F4N4O3S
Molecular Weight
492.45
References & Citations
[1]Preclinical Development of ONC1-13B, Novel Antiandrogen for Prostate Cancer Treatment
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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