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NNC 55-0396

CAT: 0804-HY-50722-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-50722-01Size:1 mg
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Description
NNC 55-0396 is a highly selective T-type calcium channel blocker with an IC50 value of 6.8 μM for Cav3.1 T-type channels. NNC 55-0396 can be used for the research of neurological disease research[1][2].
CAS Number
357400-13-6
Product Name Alternative
NNC 55-0396 dihydrochloride
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nnc-55-0396.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL
Smiles
O=C(C1CC1)O[C@@]2(CCN(CCCC3=NC4=CC=CC=C4N3)C)[C@@H](C(C)C)C5=C(C=C(F)C=C5)CC2.[H]Cl.[H]Cl
Molecular Formula
C30H40Cl2FN3O2
Molecular Weight
564.56
References & Citations
[1]Arnulfo Quesadaa, Peter H. Bui, Gregg E. Homanics, et al. Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. European Journal of Pharmacology. 2011,659 (1) : 30-36.|[2]Hideto Miwa, Jinsoo Koh, Yoshinori Kajimoto, et al. Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats. Pharmacology Biochemistry and Behavior. 2011,97 (4) : 656-659.|[3]Huang L, Keyser BM, Tagmose TM, et al. NNC 55-0396 [ (1S,2S) -2- (2- (N-[ (3-benzimidazol-2-yl) propyl]-N-methylamino) ethyl) -6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. J Pharmacol Exp Ther. 2004 Apr;309 (1) :193-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
T-type calcium channel

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