SF-22

• Description :

  SF-22 is a potent and brain-penetrant antagonist of neuropeptide Y receptor (Y2R), with the IC50 value of 750 nM. SF-22 plays an important role in neurological disease[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H319

• Target :

  Neuropeptide Y Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/sf-22.html

• Purity :

  99.49

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=CC=CC=C1C2=CC=CC=C2)C3=CC=C(C)C(S(=O)(NC4=CC(C)=CC=C4C)=O)=C3

• Molecular Formula :

  C28H26N2O3S

• Molecular Weight :

  470.58

• Precautions :

  P264-P280-P305+P351+P338

• References & Citations :

  [1]P Brothers, et al. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screeningShaun. Mol Pharmacol. 2010 Jan;77 (1) :46-57.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [824981-55-7]