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SF-9-2

CAT: 0804-HY-175236Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175236Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SF-9-2 is a PD-L1/PD-1 binding inhibitor (IC50 = 24.9 nM) . SF-9-2 inhibits epithelial-mesenchymal transition, migration, invasion, and proliferation of SK-N-SH cells, and also induces apoptosis and cell cycle arrest. SF-9-2 blocks PD-L1-induced SK-N-SH cell growth through the MAPK signaling pathway. SF-9-2 restores GSK-3β activity and enhances PD-L1 degradation through the ubiquitin-proteasome pathway. SF-9-2 inhibits tumor growth in the SK-N-SH NOG mouse model without significant toxicity. SF-9-2 also acts as an immune checkpoint inhibitor, blocking PD-L1 to restore T cell function. SF-9-2 can be used in neuroblastoma research[1].
CAS Number
[3053768-78-5]
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Cadherin; Caspase; ERK; GSK-3; IFNAR; JNK; p38 MAPK; PD-1/PD-L1
Related Pathways
Apoptosis; Cytoskeleton; Immunology/Inflammation; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer
Smiles
N#CC1=CC(COC2=C(C=CC(OCC3=C(C(C4=CC=CC=C4F)=CC=C3)CF)=C2)CNCCO)=CN=C1
Molecular Formula
C30H27F2N3O3
Molecular Weight
515.55
References & Citations
[1]Jianwei Wang et al. Antineuroblastoma Activity Evaluation and Mechanism of Novel PD-L1 Small Molecule Inhibitors through Immune and Non-Immune Pathways. ACS Pharmacol. Transl. Sci.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; GSK-3β

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