MRS4458

CAT: 0804-HY-124987Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-124987Size:1 Each
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Description
MRS4458 is a P2Y14 receptor antagonist with anti-inflammatory activity. MRS4458 mediates inflammatory activity by activating the motility of neutrophils. The design of MRS4458 is based on the interaction with the P2Y14 receptor and optimized by molecular dynamic simulation. MRS4458 performs well in terms of shape and complementarity with the receptor. The prediction that the 5-phenyl group of MRS4458 is substituted with thiophene is generally consistent with empirical results. The biological activity of MRS4458 was verified by fluorescence assay, showing its potent antagonistic effect[1].
CAS Number
[2225834-49-9]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mrs4458.html
Smiles
O=C(C1=CC(C2=CC=C(C(NCCCN)=O)S2)=CC(N3N=NC(C4=CC=C(C(F)(F)F)C=C4)=C3)=C1)O
Molecular Formula
C24H20F3N5O3S
Molecular Weight
515.51
References & Citations
[1]Structure-Guided Modification of Heterocyclic Antagonists of the P2Y14 Receptor
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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