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MRS8454

CAT: 0804-HY-178783Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178783Size:1 Each
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Description
MRS8454 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR) . MRS8454 can significantly enhance the maximum effect of the standard agonist Cl-IB-MECA by approximately 286%-300%, and significantly reduce its EC50 value. MRS8454 effectively enhances the ability of A3AR agonists to inhibit the cAMP accumulation induced by Forskolin (HY-15371) . MRS8454 can be used for the development of molecular probes[1].
UNSPSC
12352005
Target
Adenosine Receptor
Related Pathways
GPCR/G Protein
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Smiles
CCCC(C(N1CC2=CC=CC=C2)=NC3=C1C4=CC=CC=C4N=C3NC5=CC=C(C#CCCCCCCCCCN6CCCCC6)C=C5)CCC
Molecular Formula
C46H59N5
Molecular Weight
681.99
References & Citations
[1]Kurma SH, et al. Bitopic A3 Adenosine Receptor Molecular Probes: Positive Allosteric Modulation and Noncanonical Activation. J Med Chem. 2025 Oct 9;68 (19) :20717-20740.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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