Human Insulin Recombinant Rabbit Monoclonal Antibody [PSH04-16] - BSA and Azide free (Detector)

Human Insulin Recombinant Rabbit Monoclonal Antibody [PSH04-16] - BSA and Azide free (Detector)

• Description: This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
• Product Name Alternative: IDDM antibody IDDM1 antibody IDDM2 antibody ILPR antibody ins antibody INS_HUMAN antibody Insulin A chain antibody Insulin B chain antibody IRDN antibody MODY10 antibody Preproinsulin antibody Proinsulin antibody Proinsulin precursor antibody
• Abbreviation: INS Insulin Insulin B chain Insulin A chain
• CAS Number: 9000-83-3
• Swiss Prot: P01308 Human
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within human Insulin aa 15-110.
• Isotype: IgG
• Clone: PSH04-16
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: ELISA (Det)
• Positive Control: Human insulin.
• Concentration: 1 mg/mL
• Dilution: ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH04-15] to Human Insulin (Capture) (HA722096). The reference range value is 31.25-2,000pg/mll.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4).
• Molecular Weight: Predicted band size: 12 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes