Deoxycytidine triphosphate-15N3,d14 (dilithium)

• UNSPSC Description:

  Deoxycytidine triphosphate-15N3,d14 (dCTP-15N3,d14 dilithium; 2′-Deoxycytidine-5′-triphosphate-15N3,d14) dilithium is deuterium and 15N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

• Target Antigen:

  DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  O=P(O[2H])(O[Li])OP(OP(OC([2H])([2H])[C@]1([2H])[C@](O[2H])([2H])C([2H])([2H])[C@@]([15N]2C([15N]=C([15N]([2H])[2H])C([2H])=C2[2H])=O)([2H])O1)(O[2H])=O)(O[Li])=O

• Molecular Weight:

  496.09

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]M H Tattersall, et al. Deoxyribonucleoside triphosphates in human cells: changes in disease and following exposure to drugs. Eur J Clin Invest. 1975 Apr;5(2):191-202.|[3]A W Harris, et al. Effect of thymidine on the sensitivity of cultured mouse tumor cells to 1-beta-D-arabinofuranosylcytosine. Cancer Res. 1979 Feb;39(2 Pt 1):538-41.|[4]B A Bladergroen, et al. CTP:phosphoethanolamine cytidylyltransferase. Biochim Biophys Acta. 1997 Sep 4;1348(1-2):91-9.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported