EIF2AK2 Antibody [APR15805G]

CAT: 0882-APR15805G-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR15805G-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Tissue Location: Highly expressed in thymus, spleen and bone marrow compared to non-hematopoietic tissues such as small intestine, liver, or kidney tissues. Colocalizes with GSK3B and TAU in the Alzheimer disease (AD) brain. Elevated levels seen in breast and colon carcinomas, and which correlates with tumor progression and invasiveness or risk of progression.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality EIF2AK2 Antibody [APR15805G].

Synonyms

Interferon-induced, double-stranded RNA-activated protein kinase, Eukaryotic translation initiation factor 2-alpha kinase 2, eIF-2A protein kinase 2, Interferon-inducible RNA-dependent protein kinase, P1/eIF-2A protein kinase, Protein kinase RNA-activated, PKR, Protein kinase R, Tyrosine-protein kinase EIF2AK2, p68 kinase, EIF2AK2, PKR, PRKR

Gene Name

EIF2AK2

Gene ID

5610

UniProt

P19525

Chromosomal Location

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Nuclear localization is elevated in acute leukemia, myelodysplastic syndrome (MDS), melanoma, breast, colon, prostate and lung cancer patient samples or cell lines as well as neurocytes from advanced Creutzfeldt- Jakob disease patients.

Applications

WB, IF

Dilution

IF--1:25 WB--1:1000-1:2000

Function

1883525119507191191898532112365121072047229481392322954322381929191898532112365122948139232295431183638019189853201711141984025921710204231152762339903511836380222146621922932020395957229481392308447623372823108485801512186715229216206859592068595922801494

Molecular Weight

62094

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/?term=5610

Uniprot URL

https://www.uniprot.org/uniprot/P19525

UniProtKB · P19525

Interferon-induced, double-stranded RNA-activated protein kinase

E2AK2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P19525
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: EIF2AK2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.7.11.1
Processing: —
Secondary accessions: A8K3P0, D6W584, E9PC80, Q52M43, Q7Z6F6, Q9UIR4

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseHost-virus interactionImmunityInnate immunityTranscriptionTranscription regulation

Ligand

ATP-bindingMagnesiumNucleotide-binding

Cellular component

CytoplasmNucleus

Disease

Disease variantDystonia

Molecular function

KinaseRNA-bindingSerine/threonine-protein kinaseTransferaseTyrosine-protein kinase

Domain

Repeat

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Alternative Products

Catalog	Name
GWB-MM457G	EIF2AK2 Antibody