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PKR/EIF2AK2 Rabbit mAb (AMR12759N)

CAT: 0882-AMR12759N-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0882-AMR12759N-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PKR/EIF2AK2 Rabbit mAb (APR24494N5) .
Synonyms
EIF2AK1; PKR; PPP1R83; PRKR; Eif2ak2; EIF2AK2
Gene ID
5610
UniProt
P19525
Cellular Locus
Cytoplasm, Nucleus, perinuclear region
Dilution
WB 1:500 - 1:2000
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 68kDa Observed MW: 70KDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5610
Uniprot URL
https://www.uniprot.org/uniprot/P19525
AA Sequence
Email for sequence

UniProtKB · P19525

Interferon-induced, double-stranded RNA-activated protein kinase

E2AK2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P19525
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EIF2AK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
A8K3P0, D6W584, E9PC80, Q52M43, Q7Z6F6, Q9UIR4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseHost-virus interactionImmunityInnate immunityTranscriptionTranscription regulation

Ligand

ATP-bindingMagnesiumNucleotide-binding

Cellular component

CytoplasmNucleus

Disease

Disease variantDystonia

Molecular function

KinaseRNA-bindingSerine/threonine-protein kinaseTransferaseTyrosine-protein kinase

Domain

Repeat

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