GABA A Receptor α4 rabbit pAb

GABA A Receptor α4 rabbit pAb

• Description: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene. [provided by RefSeq, Feb 2011],
• Synonyms: GABRA4; Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor subunit alpha-4
• Gene ID: 2557
• UniProt: P48169
• Cellular Locus: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse
• Immunogen: Synthetic Peptide of GABA A Receptor α4 AA range: 149-199
• Clonality: Polyclonal
• Validated Applications: WB, IHC, IF
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:1000-2000, IHC 1:100-200
• Molecular Weight: 62kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.