GABA B Receptor 2 rabbit pAb

GABA B Receptor 2 rabbit pAb

• Description: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence. [provided by RefSeq, Jan 2010],
• Synonyms: GABBR2; GPR51; GPRC3B; Gamma-aminobutyric acid type B receptor subunit 2; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2; G-protein coupled receptor 51; HG20
• Gene ID: 9568
• UniProt: O75899
• Cellular Locus: Cell membrane ; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein. Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane..
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse
• Immunogen: Synthetic Peptide of GABA B Receptor 2 AA range: 785-835
• Clonality: Polyclonal
• Validated Applications: IHC, IF
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: IHC 1:100-200
• Molecular Weight: 106kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.