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TKNK rabbit pAb

CAT: 0855-ES12686-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES12686-01Size:50 µL
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Background
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Description
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016],
UniProt
Q9UHF0
Swiss Prot
Q9UHF0
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human TKNK AA range: 6-56
Target
TKNK
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Secreted.
Gene ID (Human)
6866

UniProtKB · Q9UHF0

Tachykinin-3

TKNK_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UHF0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TAC3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q6IAG2, Q71BC6, Q71BC9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

AmidationCleavage on pair of basic residues

Disease

Disease variantHypogonadotropic hypogonadism

Molecular function

Neuropeptide

Cellular component

Secreted

Domain

Signal

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