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Nifurtimox-d4

CAT: 0804-HY-W040073S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W040073S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nifurtimox-d4 is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH) .
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Lactate Dehydrogenase; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Solubility
10 mM in DMSO
Smiles
O=[N+](C1=CC=C(/C=N/N2C(C)C([2H])([2H])S(C([2H])([2H])C2)(=O)=O)O1)[O-]
Molecular Formula
C10H9D4N3O5S
Molecular Weight
291.32
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Cabanillas Stanchi KM, et al. Nifurtimox reduces N-Myc expression and aerobic glycolysis in neuroblastoma. Cancer Biol Ther. 2015;16 (9) :1353-63.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Trypanosoma

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