FO-4-15

• Description :

  FO-4-15 is an mGluR1/CaMKIIα activator. FO-4-15 has a protective effect against H2O2 in human neuroblastoma (SH-SY5Y) cells. FO-4-15 can improve cognitive impairment in Alzheimer’s disease mice by activating the mGluR1/CaMKIIα pathway, and can reduce Aβ accumulation, hyperphosphorylated Tau, and synaptic damage[1].

• UNSPSC :

  12352005

• Target :

  CaMK; mGluR; Tau Protein

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Smiles :

  O=S(N1CCN(CC2=NC(C3=CC=CO3)=NO2)CC1)(C4=CC=C(C)C=C4)=O

• Molecular Formula :

  C18H20N4O4S

• Molecular Weight :

  388.44

• References & Citations :

  [1]Luo ZH, et al. Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3xTg mice by activating the mGluR1/CaMKIIα pathway. Acta Pharmacol Sin. 2024 Aug 16.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1030759-58-0]