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Ch282-5

CAT: 0804-HY-164468Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164468Size:1 Each
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Description
Ch282-5 is an orally active inhibitor targeting the Bcl-2 protein, inducing mitochondria-dependent apoptosis (Apoptosis) by disrupting mitophagy and the mTOR pathway. Ch282-5 exhibits antiproliferative activity against colorectal cancer cells both in vitro and in vivo, and it also inhibits metastasis. Additionally, Ch282-5 enhances Oxaliplatin -induced autophagy (Autophagy) by downregulating the Mcl-1 protein and increasing platelet count, alleviating adverse effects of Navitoclax (HY-10087).
CAS Number
65891-87-4
UNSPSC
12352005
Target
Apoptosis; Autophagy; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ch282-5.html
Smiles
CC(C1=C(O)C(O)=C(/C=N/CCS(=O)(O[Na])=O)C(C(C(C(C2=O)=C(C)C(C3=C2C(/C=N/CCS(=O)(O[Na])=O)=C(O)C(O)=C3C(C)C)=O)=C4C)=O)=C1C4=O)C
Molecular Formula
C34H34N2Na2O14S2
Molecular Weight
804.75
References & Citations
[1]Wang X, et al. A Novel Bioavailable BH3 Mimetic Efficiently Inhibits Colon Cancer via Cascade Effects of Mitochondria. Clin Cancer Res. 2016 Mar 15;22 (6) :1445-58.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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