Withanolide A

Withanolide A

• CAS Number: 32911-62-9
• UNSPSC Description: Withanolide A is an orally active extract from the Indian herb Ashwagandha. Withanolide A can induce apoptosis. Withanolide A has anti-inflammatory and antitumor activity. Withanolide A can be used in the study of neurodegenerative diseases[1][2][3][4].
• Target Antigen: Apoptosis; Notch
• Type: Natural Products
• Related Pathways: Apoptosis;Neuronal Signaling;Stem Cell/Wnt
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cancer; Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/withanolide-a.html
• Purity: 98.22
• Solubility: DMSO : 10 mg/mL (ultrasonic)
• Smiles: O=C1O[C@@]([H])([C@@](C)([C@H]2CC[C@]3([C@@]4([C@H]5[C@@H]([C@@](O)(CC=CC6=O)[C@]6([C@]4(CC[C@@]32C)[H])C)O5)[H])[H])O)CC(C)=C1C
• Molecular Weight: 470.60
• References & Citations: [1]Kuboyama T, et al. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br J Pharmacol. 2005 Apr;144(7):961-71..|[2]Zhang X, et al. Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A. Gynecol Oncol. 2012 Mar;124(3):606-12.|[3]Pathak P, et al. Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing nitric oxide generation. J Ethnopharmacol. 2021 Oct 5;278:114296.|[4]Baitharu I, et al. Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxia. PLoS One. 2014 Oct 13;9(10):e105311.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, protect from light)
• Clinical Information: No Development Reported