Withanolide B

Withanolide B

• CAS Number: 56973-41-2
• UNSPSC Description: Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects[1][2][3].
• Target Antigen: ERK; Wnt; β-catenin
• Type: Natural Products
• Related Pathways: MAPK/ERK Pathway;Stem Cell/Wnt
• Field of Research: Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/withanolide-b.html
• Purity: 99.0
• Solubility: Acetone : 1 mg/mL (ultrasonic;warming;heat to 60°C)|DMSO : 3.33 mg/mL (ultrasonic)
• Smiles: C[C@@]12[C@]3([H])[C@@]([C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@@H]([C@@]5([H])CC(C)=C(C(O5)=O)C)C)C)([H])[C@H]6[C@@H]([C@]1(CC=CC2=O)O)O6
• Molecular Weight: 454.60
• References & Citations: [1]Kuang Z, et, al. Withanolide B promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via ERK1/2 and Wnt/β-catenin signaling pathways. Int Immunopharmacol. 2020 Nov;88:106960. |[2]Dubey S, et, al. Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives. Int J Biol Macromol. 2021 Mar 15;173:56-65. |[3]Sivanandha G, et, al. Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. PLoS One. 2014 Aug 4;9(8):e104005.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported