Anti-Ms CD5 PE

CAT: 0270-1P-748-C100Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0270-1P-748-C100Size:0.1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR) . CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells it seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.) . The CD5+ popuation is expanded in some autoimmune disorders (rheumatoid arthritis, etc.) . Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells.
Certification
RUO
Reactivity
Mouse
Immunogen
Murine thymus or spleen cells
Target Antigen
CD5
Clone
53-7.3
Applications
FC (QC tested)
Concentration
0.5 mg/mL
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Wang JY, Lee J, Yan M, Rho JH, Roehrl MH: Dermatan sulfate interacts with dead cells and regulates CD5 (+) B-cell fate: implications for a key role in autoimmunity. Am J Pathol. 2011 May;178 (5) :2168-76., URL: https://www.ncbi.nlm.nih.gov/pubmed/?term=Wang+JY%2C+Lee+J%2C+Yan+M%2C+Rho+JH%2C+Roehrl+MH%3A+Dermatan+sulfate+interacts+with+dead+cells+and+regulates+CD5 (%2B) +B-cell+fate%3A+implications+for+a+key+role+in+autoimmunity. , *Sestero CM, McGuire DJ, De Sarno P, Brantley EC, Soldevila G, Axtell RC, Raman C: CD5-dependent CK2 activation pathway regulates threshold for T cell anergy. J Immunol. 2012 Sep 15;189 (6) :2918-30, URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=sestero+cm+brantley+ec , *Jeong YI, Hong SH, Cho SH, Lee WJ, Lee SE: Induction of IL-10-producing CD1dhighCD5+ regulatory B cells following Babesia microti-infection. PLoS One. 2012;7 (10) :e46553. doi: 10.1371/journal.pone.0046553., URL: http://www.ncbi.nlm.nih.gov/pubmed/23071588
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The rat monoclonal antibody 53-7.3 recognizes an extracellular epitope of CD5, a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most of thymocytes and B-1 lymphocytes.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Isotype
Rat IgG2a kappa

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