Anti-Hu CD263 PE

TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5) .

Human

TRAIL-R3-hIgGhc fusion protein

CD263

TRAIL-R3-02

FC (QC tested)

0.1 mg/mL

PE

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

*Deligezer U, Dalay N: Expression of the TRAIL Receptors in Blood Mononuclear Cells in Leukemia. Pathol Oncol Res. 2007;13 (4) :290-4., URL: https://www.ncbi.nlm.nih.gov/pubmed/18158563?ordin, *Falschlehner C, Emmerich CH, Gerlach B, Walczak H: TRAIL signalling: decisions between life and death. Int J Biochem Cell Biol. 2007;39 (7-8) :1462-75., URL: https://www.ncbi.nlm.nih.gov/pubmed/17403612?ordin, *Mérino D, Lalaoui N, Morizot A, Schneider P, Solary E, Micheau O: Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol. 2006 Oct;26 (19) :7046-55., URL: https://www.ncbi.nlm.nih.gov/pubmed/16980609?ordin, *Sanlioglu AD, Dirice E, Aydin C, Erin N, Koksoy S, Sanlioglu S. Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells. BMC Cancer. 2005 May 25;5 (1) :54., URL: https://www.ncbi.nlm.nih.gov/pubmed/15916713?ordin, *Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FK: Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc Natl Acad Sci U S A. 2005 Dec 13;102 (50) :18099-104., URL: https://www.ncbi.nlm.nih.gov/pubmed/16319225?ordin

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

The antibody TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.

Flow cytometry: Recommended dilution: 1-6 μg/ml.