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Anti-Hu CD267 PE

CAT: 0270-1P-162-T100Size: 100 TestsDry Ice: NoHazardous: No
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CAT#:0270-1P-162-T100Size:100 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD267 / TACI (transmembrane activator calcium modulator and cyclophilin ligand interactor), a TNFR superfamily transmembrane protein, is expressed on B cells (predominantly on CD27+ memory cells), multiple myeloma cells and B cell chronic lymphocytic leukemia (B-CLL) . Its triggering leads to activation of the transcription factors NFAT, AP1, and NF-kappa-B. It plays a crucial role in humoral immunity. Mutations in CD267 are associated with common variable immunodeficiency and IgA deficiency.
Certification
RUO
Reactivity
Human
Immunogen
CD267-transfected RBL cells
Target Antigen
CD267
Clone
1A1
Applications
FC (QC tested)
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Koarada S, Tada Y, Suematsu R, Soejima S, Inoue H, Ohta A, Nagasawa K: Phenotyping of P105-negative B cell subsets in patients with systemic lupus erythematosus. Clin Dev Immunol. 2012;2012:198206., URL: http://www.ncbi.nlm.nih.gov/pubmed/21961021
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The rat monoclonal antibody 1A1 recognizes an extracellular epitope of CD267 / TACI, a 32 kDa type III transmembrane protein expressed by B cells and possibly by some activated T cells.
Applications Notes
6
Isotype
Rat IgG2a kappa

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