Anti-Hu Ig Lambda Light Chain PE

Anti-Hu Ig Lambda Light Chain PE

• Background: Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains (five heavy chains types) and two light chains (kappa, lambda both having a molecular weight of 22.5kDa). Kappa and lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of kappa to lambda is 70:30.
• Specifications: The antibody 4C2 reacts with lambda light chains (22.5 kDa) of human immunoglobulin.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Negative Species: Rabbit, Hamster, Sheep, Guinea pig, Goat
• Target Antigen: Ig Lambda Light Chain
• Isotype: IgG1
• Clone: 4C2
• Applications: Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
• Validated Applications: FC
• Format: PE
• Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *Os A, Bürgler S, Ribes AP, Funderud A, Wang D, Thompson KM, Tj248nnfjord GE, Bogen B, Munthe LA: Chronic lymphocytic leukemia cells are activated and proliferate in response to specific T helper cells. Cell Rep. 2013 Aug 154(3):566-77., URL: https://www.ncbi.nlm.nih.gov/pubmed/23933259,
• Other References: *Franklin EC: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh). 1975194:77-95., URL: https://www.ncbi.nlm.nih.gov/pubmed/47690?ordinalp,
• Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.