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Anti-Hu CD109 PE

CAT: 0270-1P-131-T100Size: 100 TestsDry Ice: NoHazardous: No
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CAT#:0270-1P-131-T100Size:100 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD109, also known as the Gov platelet alloantigen, is a GPI-anchored glycoprotein which localizes to the surface of platelets, activated T-cells, and endothelial cells, as well as of various hematopoietic cells and T cell lines. The protein binds to and negatively regulates signaling by transforming growth factor beta (TGF-beta) . Multiple transcript variants encoding different isoforms have been found for this gene. The Gov antigen system is involved in platelet transfusion reaction, posttransfusion purpura and in neonatal alloimmune thrombocytopenia.
Certification
RUO
Reactivity
Human
Immunogen
WERI-RB-1 retinoblastoma cell line
Target Antigen
CD109
Clone
W7C5
Applications
FC (QC tested)
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, Andriolo G, Sun B, Zheng B, Zhang L, Norotte C, Teng PN, Traas J, Schugar R, Deasy BM, Badylak S, Buhring HJ, Giacobino JP, Lazzari L, Huard J, Péault B: A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell. 2008 Sep 11;3 (3) :301-13. doi: 10.1016/j.stem.2008.07.003., URL: http://www.ncbi.nlm.nih.gov/pubmed/18786417 , *Giesert C, Marxer A, Sutherland DR, Schuh AC, Kanz L, Buhring HJ: Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets. Ann N Y Acad Sci. 2003 May;996:227-30., URL: https://pubmed.ncbi.nlm.nih.gov/12799300/
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody W7C5 recognizes CD109, an approximately 165 kDa GPI-anchored extracellular protein expressed mainly on various hematopoietic cells, activated T lymphoblasts, activated platelets, and endothelial cells.
Applications Notes
6
Isotype
Mouse IgG1

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