Anti-Hu CD109 Purified

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

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CAT:

270-11-131-C100

Size:

0.1 mg

Price:

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Anti-Hu CD109 Purified

Background: CD109, also known as the Gov platelet alloantigen, is a GPI-anchored glycoprotein which localizes to the surface of platelets, activated T-cells, and endothelial cells, as well as of various hematopoietic cells and T cell lines. The protein binds to and negatively regulates signaling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. The Gov antigen system is involved in platelet transfusion reaction, posttransfusion purpura and in neonatal alloimmune thrombocytopenia.
Specifications: The mouse monoclonal antibody W7C5 recognizes CD109, an approximately 165 kDa GPI-anchored extracellular protein expressed mainly on various hematopoietic cells, activated T lymphoblasts, activated platelets, and endothelial cells.
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: WERI-RB-1 retinoblastoma cell line
Target Antigen: CD109
Isotype: IgG1
Clone: W7C5
Applications: Flow cytometry: Recommended dilution: 1-4 μg/mL.
Validated Applications: FC
Concentration: 1 mg/mL
Format: Purified
Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, Andriolo G, Sun B, Zheng B, Zhang L, Norotte C, Teng PN, Traas J, Schugar R, Deasy BM, Badylak S, Buhring HJ, Giacobino JP, Lazzari L, Huard J, Péault B: A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell. 2008 Sep 113(3):301-13. doi: 10.1016/j.stem.2008.07.003., URL: http://www.ncbi.nlm.nih.gov/pubmed/18786417 ,*Giesert C, Marxer A, Sutherland DR, Schuh AC, Kanz L, Buhring HJ: Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets. Ann N Y Acad Sci. 2003 May996:227-30., URL: https://pubmed.ncbi.nlm.nih.gov/12799300/,
Storage Conditions: Store at 2-8°C. Do not freeze.

Complementary Product Range

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