Products for Research Use Only
RegisterLogin

Anti-Hu CD140a APC

CAT: 0270-1A-589-T100Size: 100 TestsDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0270-1A-589-T100Size:100 Tests
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CD140a / PDGF-RA (platelet-derived growth factor receptor alpha) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140a forms homodimers, or heterodimerizes with CD140b / PDGF-RB. Whereas CD140b induces in different cell types their proliferation and migration, the role of CD140a is more controversial, with pro-proliferative or anti-proliferative effects. CD140a has early developmental functions, mediates mesodermal cell migration, and later acts in signaling associated in epithelial-mesenchymal interactions.
Certification
RUO
Reactivity
Human
Immunogen
CD140a-transfected NIH 3T3 cells
Target Antigen
CD140a
Clone
16A1
Applications
FC (QC tested)
Format
APC
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Ricono JM, Wagner B, Gorin Y, Arar M, Kazlauskas A, Choudhury GG, Abboud HE: PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA. Am J Physiol Renal Physiol. 2009 Feb;296 (2) :F406-17. (IF), URL: https://pubmed.ncbi.nlm.nih.gov/19019919/
Other References
*Faraone D, Aguzzi MS, Toietta G, Facchiano AM, Facchiano F, Magenta A, Martelli F, Truffa S, Cesareo E, Ribatti D, Capogrossi MC, Facchiano A: Platelet-derived growth factor-receptor alpha strongly inhibits melanoma growth in vitro and in vivo. Neoplasia. 2009 Aug;11 (8) :732-42., URL: https://www.ncbi.nlm.nih.gov/pubmed/19649203?itool, *Schmahl J, Rizzolo K, Soriano P: The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev. 2008 Dec 1;22 (23) :3255-67., URL: https://www.ncbi.nlm.nih.gov/pubmed/19056881?itool, *French WJ, Creemers EE, Tallquist MD: Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol Cell Biol. 2008 Sep;28 (18) :5646-57., URL: https://www.ncbi.nlm.nih.gov/pubmed/18606782?itool, *Andrae J, Gallini R, Betsholtz C: Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008 May 15;22 (10) :1276-312., URL: https://www.ncbi.nlm.nih.gov/pubmed/18483217?itool
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody 16A1 recognizes an extracellular epitope of CD140a / PDGF-RA, the 170 kDa alpha chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in various tumours.
Applications Notes
6
Isotype
Mouse IgG1 kappa

Related Products

CatalogName
11-589-C100Anti-Hu CD140a Purified
1P-589-T100Anti-Hu CD140a PE
1B-589-C025Anti-Hu CD140a Biotin
1P-589-T025Anti-Hu CD140a PE
1F-589-T100Anti-Hu CD140a FITC
11-589-C025Anti-Hu CD140a Purified
1F-589-T025Anti-Hu CD140a FITC
1B-589-C100Anti-Hu CD140a Biotin
1A-590-T025Anti-Hu CD140b APC
1A-590-T100Anti-Hu CD140b APC

Alternative Products

CatalogName
MBS1800061-01Anti-Hu CD140a FITC
MBS1800059-01Anti-Hu CD140a APC
MBS1800060-01Anti-Hu CD140a Biotin
MBS1800062-01Anti-Hu CD140a PE
MBS1800058-01Anti-Hu CD140a Purified
MBS1802409-01Anti-Hu CD140a PE-Cy7
M00366-1Anti-Hu CD140a Purified PDGFRA Monoclonal Antibody
GTR18320702Mouse Hu CD140a Purified, clone 16A1 (Monoclonal) Antibody
CPA8642-01Anti-CD140a Antibody
MBS9471803-01PE anti-human CD140a

Popular Products