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Anti-Hu CD140b APC

CAT: 0270-1A-590-T100Size: 100 TestsDry Ice: NoHazardous: No
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CAT#:0270-1A-590-T100Size:100 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD140b / PDGF-RB (platelet-derived growth factor receptor beta) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a / PDGF-RA. Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumours such as medulloblastoma.
Certification
RUO
Reactivity
Human
Immunogen
CD140b-transfected NIH 3T3 cells
Target Antigen
CD140b
Clone
18A2
Applications
FC (QC tested)
Format
APC
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Fekete N, Rojewski MT, Fürst D, Kreja L, Ignatius A, Dausend J, Schrezenmeier H: GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC. PLoS One. 2012;7 (8) :e43255. doi: 10.1371/journal.pone.0043255, URL: https://www.ncbi.nlm.nih.gov/pubmed/22905242
Other References
*Andrae J, Gallini R, Betsholtz C: Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008 May 15;22 (10) :1276-312., URL: https://www.ncbi.nlm.nih.gov/pubmed/18483217?itool, *French WJ, Creemers EE, Tallquist MD: Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol Cell Biol. 2008 Sep;28 (18) :5646-57., URL: https://www.ncbi.nlm.nih.gov/pubmed/18606782?itool, *Schmahl J, Rizzolo K, Soriano P: The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev. 2008 Dec 1;22 (23) :3255-67., URL: https://www.ncbi.nlm.nih.gov/pubmed/19056881?itool, *Faraone D, Aguzzi MS, Toietta G, Facchiano AM, Facchiano F, Magenta A, Martelli F, Truffa S, Cesareo E, Ribatti D, Capogrossi MC, Facchiano A: Platelet-derived growth factor-receptor alpha strongly inhibits melanoma growth in vitro and in vivo. Neoplasia. 2009 Aug;11 (8) :732-42., URL: https://www.ncbi.nlm.nih.gov/pubmed/19649203?itool
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The monoclonal antibody 18A2 recognizes an extracellular epitope of CD140b / PDGF-RB, the 180-190 kDa beta chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative roles.
Applications Notes
6
Isotype
Mouse IgG1

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