Anti-Hu CD140a Biotin

Anti-Hu CD140a Biotin

• Background: CD140a / PDGF-RA (platelet-derived growth factor receptor alpha) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140a forms homodimers, or heterodimerizes with CD140b / PDGF-RB. Whereas CD140b induces in different cell types their proliferation and migration, the role of CD140a is more controversial, with pro-proliferative or anti-proliferative effects. CD140a has early developmental functions, mediates mesodermal cell migration, and later acts in signaling associated in epithelial-mesenchymal interactions.
• Specifications: The mouse monoclonal antibody 16A1 recognizes an extracellular epitope of CD140a / PDGF-RA, the 170 kDa alpha chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in various tumours.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: CD140a-transfected NIH 3T3 cells
• Target Antigen: CD140a
• Isotype: Igg1 κ
• Clone: 16A1
• Applications: Flow cytometry: Recommended dilution: 1-2 μg/mL.
• Validated Applications: FC, ICC
• Concentration: 1 mg/mL
• Format: Biotin
• Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Other References: *Faraone D, Aguzzi MS, Toietta G, Facchiano AM, Facchiano F, Magenta A, Martelli F, Truffa S, Cesareo E, Ribatti D, Capogrossi MC, Facchiano A: Platelet-derived growth factor-receptor alpha strongly inhibits melanoma growth in vitro and in vivo. Neoplasia. 2009 Aug11(8):732-42., URL: https://www.ncbi.nlm.nih.gov/pubmed/19649203?itool,*Schmahl J, Rizzolo K, Soriano P: The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev. 2008 Dec 122(23):3255-67., URL: https://www.ncbi.nlm.nih.gov/pubmed/19056881?itool,*French WJ, Creemers EE, Tallquist MD: Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol Cell Biol. 2008 Sep28(18):5646-57., URL: https://www.ncbi.nlm.nih.gov/pubmed/18606782?itool,*Andrae J, Gallini R, Betsholtz C: Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008 May 1522(10):1276-312., URL: https://www.ncbi.nlm.nih.gov/pubmed/18483217?itool,
• Storage Conditions: Store at 2-8°C. Do not freeze.