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Anti-Hu CD193 APC

CAT: 0270-1A-161-T100Size: 100 TestsDry Ice: NoHazardous: No
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CAT#:0270-1A-161-T100Size:100 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD193 / CCR3 is a G-protein coupled receptor for several chemokines, namely CCL11 (eotaxin), CCL26 (eotaxin-3), CCL7 (MCP-4), or CCL5 (RANTES) . It is highly expressed on eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. CD193 is the key eosinophil chemokine receptor responsible for regulation of eosinophil migration and function. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1.
Certification
RUO
Reactivity
Human
Immunogen
Human CD193 transfectants
Target Antigen
CD193
Clone
5E8
Applications
FC (QC tested)
Format
APC
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Morshed M, Hlushchuk R, Simon D, Walls AF, Obata-Ninomiya K, Karasuyama H, Djonov V, Eggel A, Kaufmann T, Simon HU, Yousefi S: NADPH oxidase-independent formation of extracellular DNA traps by basophils. J Immunol. 2014 Jun 1;192 (11) :5314-23., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=morshed+m+hlushchuk+r+simon+d
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody 5E8 recognizes an extracellular epitope of CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils.
Applications Notes
6
Isotype
Mouse IgG2b kappa

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